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Diagnostic Exercise: Circling and Behavioral Changes in a Cat.
K Faller1, J Leach2, R Gutierrez-Quintana1
1Neurology Unit, Small Animal Hospital, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland, United Kingdom.
Veterinary Pathology
|August 28, 2014
Summary
A rare cholesterol granuloma was diagnosed in a cat presenting with neurological signs. This intracranial mass required euthanasia due to its poor prognosis.
Area of Science:
- Veterinary Neurology
- Pathology
- Neuroimaging
Background:
- Neurological signs in cats can stem from various intracranial pathologies.
- Accurate diagnosis relies on a combination of clinical examination, advanced imaging, and histopathology.
Observation:
- A 4-year-old domestic shorthair cat exhibited circling and behavioral changes, indicative of forebrain dysfunction.
- Magnetic resonance imaging (MRI) identified a large midline intracranial mass.
- Histopathology revealed a mass with specific cellular characteristics and cholesterol deposits.
Findings:
- The intracranial mass was definitively diagnosed as a cholesterol granuloma.
- Immunohistochemistry showed positive staining for major histocompatibility complex class II antigen, CD18, and S100.
- Differential diagnosis included meningioma, highlighting the importance of detailed histopathological analysis.
Implications:
- This case expands the understanding of rare intracranial masses in feline medicine.
- Highlights the diagnostic utility of MRI and immunohistochemistry in complex neurological cases.
- Emphasizes the importance of considering cholesterol granuloma in feline neurological differentials.
