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Strategies for Assessing Autistic-Like Behaviors in Mice
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Diagnostic Exercise: Circling and Behavioral Changes in a Cat.

K Faller1, J Leach2, R Gutierrez-Quintana1

  • 1Neurology Unit, Small Animal Hospital, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland, United Kingdom.

Veterinary Pathology
|August 28, 2014
PubMed
Summary

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This summary is machine-generated.

A rare cholesterol granuloma was diagnosed in a cat presenting with neurological signs. This intracranial mass required euthanasia due to its poor prognosis.

Area of Science:

  • Veterinary Neurology
  • Pathology
  • Neuroimaging

Background:

  • Neurological signs in cats can stem from various intracranial pathologies.
  • Accurate diagnosis relies on a combination of clinical examination, advanced imaging, and histopathology.

Observation:

  • A 4-year-old domestic shorthair cat exhibited circling and behavioral changes, indicative of forebrain dysfunction.
  • Magnetic resonance imaging (MRI) identified a large midline intracranial mass.
  • Histopathology revealed a mass with specific cellular characteristics and cholesterol deposits.

Findings:

  • The intracranial mass was definitively diagnosed as a cholesterol granuloma.
  • Immunohistochemistry showed positive staining for major histocompatibility complex class II antigen, CD18, and S100.
Keywords:
braincatcholesterol cleftscholesterol granulomaimmunohistochemistrymagnetic resonance imagingmass

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  • Differential diagnosis included meningioma, highlighting the importance of detailed histopathological analysis.

    • Implications:

    • This case expands the understanding of rare intracranial masses in feline medicine.
    • Highlights the diagnostic utility of MRI and immunohistochemistry in complex neurological cases.
    • Emphasizes the importance of considering cholesterol granuloma in feline neurological differentials.