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Related Concept Videos

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

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Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
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Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to...
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Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
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Retroperitoneal fibrosis.

Martha Tzou1, David J Gazeley2, Peter J Mason3

  • 1University of Wisconsin School of Medicine & Public Health, Madison, WI, USA.

Vascular Medicine (London, England)
|August 28, 2014
PubMed
Summary
This summary is machine-generated.

Retroperitoneal fibrosis (RPF) is a rare inflammatory disease causing a mass that can obstruct ureters and lead to kidney failure. Treatment involves immunosuppressants to manage symptoms and reduce the mass, though relapses can occur.

Keywords:
IgG4-related diseaseclaudicationidiopathic retroperitoneal fibrosisperipheral artery disease

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Area of Science:

  • Nephrology
  • Vascular Surgery
  • Rheumatology

Background:

  • Retroperitoneal fibrosis (RPF) is a rare condition characterized by a fibroinflammatory mass.
  • This mass can encase vital structures like the abdominal aorta and ureters.

Observation:

  • RPF presents with constitutional symptoms, abdominal pain, and often renal insufficiency due to ureteral obstruction.
  • Vascular complications such as venous thrombosis and claudication are less common presentations.

Findings:

  • Idiopathic RPF is most common, but secondary causes include malignancy and medications.
  • Pathophysiology is unclear, but links to periaortitis and IgG4-related disease exist.

Implications:

  • Treatment focuses on symptom relief and managing complications from mass effect.
  • Immunosuppressants can induce remission, but RPF often follows a relapsing course.