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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
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Related Experiment Video

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Strategies for Assessing Autistic-Like Behaviors in Mice
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Biomarkers in autism.

Andre A S Goldani1, Susan R Downs2, Felicia Widjaja2

  • 1Universidade Federal do Rio Grande do Sul , Porto Alegre , Brazil.

Frontiers in Psychiatry
|August 28, 2014
PubMed
Summary
This summary is machine-generated.

Researchers are exploring biomarkers for autism spectrum disorder (ASD) to improve diagnosis and treatment. While promising avenues exist in genetics and metabolism, no biomarkers are currently ready for routine clinical use.

Keywords:
autism spectrum disordersbiomarkerepigeneticsgeneticsneuroimagingtreatment targets

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Area of Science:

  • Neuroscience
  • Genetics
  • Metabolic disorders

Background:

  • Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions influenced by genetic and environmental factors.
  • Identifying reliable biomarkers is crucial for targeted diagnosis and treatment of ASDs.
  • Current research focuses on genetics, neuroimaging, gene expression, and metabolism.

Purpose of the Study:

  • To review published studies on potential biomarkers for autism spectrum disorder.
  • To assess the current evidence supporting the clinical utility of identified biomarkers.
  • To highlight promising areas for future biomarker discovery in ASD.

Main Methods:

  • Systematic review of published research on autism biomarkers.
  • Analysis of studies investigating genetic, neuroimaging, gene expression, and metabolic markers.
  • Evaluation of the evidential support for each potential biomarker.

Main Results:

  • Several promising biomarkers are emerging, particularly in mitochondrial function, oxidative stress, and immune function.
  • Genetic clusters show potential for developing useful diagnostic or prognostic markers.
  • No biomarkers currently possess sufficient evidence for routine clinical application in ASD, except when specific medical conditions are suspected.

Conclusions:

  • Biomarker research for ASD is advancing, offering hope for improved diagnostic and therapeutic strategies.
  • Further rigorous research is needed to validate potential biomarkers before clinical implementation.
  • Focus on mitochondrial, oxidative stress, immune, and genetic markers shows significant promise for future ASD biomarker development.