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Updated: Apr 25, 2026

Psychophysiological Stress Assessment Using Biofeedback
Published on: July 31, 2009
Biofeedback-based training for stress management in daily hassles: an intervention study
Yuka Kotozaki1, Hikaru Takeuchi2, Atsushi Sekiguchi3
1Smart Ageing International Research Center, Institute of Development, Aging and Cancer, Tohoku University Sendai, Japan.
Biofeedback training (BFT) improved stress markers and increased gray matter volume in brain regions vulnerable to stress. This study explored the anatomical effects of BFT on stress response.
Area of Science:
- Neuroscience
- Psychology
- Health Science
Background:
- Daily hassles contribute to stress and ill health.
- Biofeedback (BF) aids stress management.
- Anatomical changes from long-term BF interventions are not well understood.
Purpose of the Study:
- Investigate the anatomical correlates of long-term biofeedback training.
- Assess the effectiveness of a combined heart rate and cerebral blood flow control task.
Main Methods:
- Randomized controlled trial with intervention and control groups.
- Intervention group performed daily 5-minute biofeedback training for 28 days.
- Assessed outcomes using MRI, psychological tests, and salivary cortisol levels.
Main Results:
- Intervention group showed improved psychological scores and reduced cortisol.
- Voxel-based morphometry revealed increased gray matter volume in the right lateral orbitofrontal cortex, left hippocampus, and left subgenual anterior cingulate cortex.
- These gray matter regions are sensitive to stress.
Conclusions:
- Biofeedback training effectively targets brain structures vulnerable to stress.
- The BFT intervention demonstrated positive effects on stress markers and brain structure.
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