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IL-17 in severe asthma. Where do we stand?
Julie Chesné1, Faouzi Braza, Guillaume Mahay
11 Institut national de la santé et de la recherche médicale (INSERM), Unité mixte de recherche (UMR) 1087, l'Institut du Thorax, Nantes, France.
American Journal of Respiratory and Critical Care Medicine
|August 28, 2014
Summary
Interleukin-17A (IL-17A) plays a key role in severe asthma, contributing to inflammation and steroid resistance. Understanding IL-17A
Area of Science:
- Pulmonology
- Immunology
- Allergy
Background:
- Severe asthma presents a significant clinical challenge, often requiring high-dose systemic steroids.
- Steroid insensitivity is a hallmark of certain severe asthma phenotypes.
- Elevated levels of Interleukin-17A (IL-17A) are consistently observed in severe asthma patients.
Purpose of the Study:
- To review current human studies on the role of IL-17A in severe asthma pathogenesis.
- To discuss the implications of IL-17A in neutrophilic inflammation and steroid resistance.
- To explore IL-17A's impact on epithelial cells and airway remodeling.
Main Methods:
- Review of updated human studies focusing on IL-17A.
- Analysis of data regarding IL-17A levels in severe asthma.
- Synthesis of information on Th17 pathway in asthma.
Main Results:
- IL-17A is implicated in inducing neutrophilic airway inflammation.
- A steroid-insensitive Th17 pathway is linked to severe asthma.
- IL-17A contributes to epithelial cell alterations and airway remodeling.
Conclusions:
- IL-17A is a critical factor in severe asthma, driving inflammation and steroid resistance.
- Targeting the IL-17A pathway may offer new therapeutic strategies for severe asthma.
- Further research into IL-17A's role is essential for managing refractory asthma.
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