Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

8.8K
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
8.8K
RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

3.0K
3.0K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

6.9K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
6.9K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

2.3K
2.3K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

16.1K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
16.1K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

3.2K
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

XIST RNA-protein complex in female-biased autoimmunity: From molecular scaffolds to new clinical biomarkers.

The Journal of investigative dermatology·2026
Same author

Somatic mutations reveal the ontogeny of human microglia.

bioRxiv : the preprint server for biology·2026
Same author

Correction: Annotation of nuclear lncRNAs based on chromatin interactions.

PloS one·2026
Same author

Fast and accurate resolution of ecDNA sequence using Cycle-Extractor.

bioRxiv : the preprint server for biology·2026
Same author

A recipe for chaos: Extrachromosomal DNA and the hallmarks of cancer.

Cell·2026
Same author

Accurate prediction of ecDNA in interphase cancer cells using deep neural networks.

Communications biology·2026
Same journal

Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex.

Nature genetics·2026
Same journal

Spatial transcriptomic analyses highlight distinct erythroid niches in mice and humans.

Nature genetics·2026
Same journal

Building up pangenome analysis block by block.

Nature genetics·2026
Same journal

Mutations in splicing factor gene U2AF1 rescue defective oncogene splicing in KRAS-mutant cancers.

Nature genetics·2026
Same journal

Assessing the effect of immune surveillance on clonal expansions in the blood.

Nature genetics·2026
Same journal

Improved heritability partitioning and enrichment analyses using summary statistics with graphREML.

Nature genetics·2026
See all related articles

Related Experiment Video

Updated: Apr 25, 2026

Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells
03:34

Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells

Published on: November 21, 2025

513

RNA switch at enhancers.

Jeffrey J Quinn1, Howard Y Chang2

  • 1Department of Bioengineering at Stanford University, Stanford, California, USA.

Nature Genetics
|August 28, 2014
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) from opposite strands of a Drosophila gene region control epigenetic states. These lncRNAs switch the vestigial Polycomb/Trithorax response element (PRE/TRE) between gene silencing and activation.

More Related Videos

A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells
06:02

A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells

Published on: October 28, 2025

674
Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

2.7K

Related Experiment Videos

Last Updated: Apr 25, 2026

Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells
03:34

Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells

Published on: November 21, 2025

513
A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells
06:02

A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells

Published on: October 28, 2025

674
Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

2.7K

Area of Science:

  • Epigenetics
  • Developmental Biology
  • RNA Biology

Background:

  • Polycomb/Trithorax response elements (PRE/TREs) are crucial for stable gene silencing or activation.
  • Understanding the mechanisms that switch epigenetic states is key to developmental processes.

Purpose of the Study:

  • To investigate the role of long noncoding RNAs (lncRNAs) in regulating epigenetic states at PRE/TREs.
  • To elucidate how lncRNAs transcribed from opposite strands of the vestigial PRE/TRE influence gene expression.

Main Methods:

  • Analysis of lncRNA transcription from the Drosophila melanogaster vestigial locus.
  • Investigating the functional impact of these lncRNAs on epigenetic modifications and gene expression.

Main Results:

  • lncRNAs transcribed from opposite strands of the vestigial PRE/TRE were identified.
  • These lncRNAs were shown to mediate the switch between silencing and activation epigenetic states.

Conclusions:

  • lncRNAs play a critical role in dynamically regulating epigenetic states at PRE/TREs.
  • The study reveals a novel mechanism for epigenetic control involving bidirectional lncRNA transcription.