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Updated: Apr 25, 2026

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses
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[Application possibility of the macrolides for the RS virus infections]

Shin-ichi Yokota, Hiroyuki Tsutsumi, Tetsuo Himi

    The Japanese Journal of Antibiotics
    |August 29, 2014
    PubMed

    Insights

    Macrolides, like clarithromycin, show promise in treating respiratory syncytial virus (RSV) infections. This review explores their immunomodulatory effects beyond antimicrobial activity for respiratory diseases.

    Area of Science:

    • Virology
    • Immunology
    • Pharmacology

    Context:

    • Human respiratory syncytial virus (RSV) causes significant respiratory illness in infants and exacerbates conditions like COPD and asthma in the elderly.
    • RSV infections are recurrent throughout life, posing a continuous health burden.

    Purpose:

    • To review the action of macrolides on respiratory syncytial virus (RSV) infections.
    • To highlight the immunomodulatory effects of macrolides, such as clarithromycin, in the context of RSV.

    Summary:

    • Macrolides possess immunomodulatory properties beyond their antimicrobial capabilities.
    • These properties have demonstrated clinical utility, particularly in managing respiratory diseases.

    Impact:

    • Provides insights into potential therapeutic strategies for RSV infections.
    • Suggests macrolides as a viable option for managing RSV-related respiratory complications.

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