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Lymphocele after pediatric kidney transplantation: incidence and risk factors

Stefano Giuliani1, Piergiorgio Gamba, Rim Kiblawi

  • 1Department of Pediatric & Neonatal Surgery, St George's Healthcare NHS Trust and University, London, UK; Division of Pediatric Surgery, Department of 'Salute della Donna e del Bambino', University of Padova, Padova, Italy.

Pediatric Transplantation
|August 29, 2014
PubMed

Insights

Post-transplant lymphocele, a complication after kidney transplants, occurred in 5.81% of pediatric patients. Key risk factors included older age, male gender, and higher BMI, with lymphocele impacting graft survival.

Area of Science:

  • Nephrology
  • Pediatric Surgery
  • Transplantation Immunology

Background:

  • Lymphocele is a recognized complication following kidney transplantation.
  • Understanding its incidence and risk factors in pediatric populations is crucial for improving outcomes.

Purpose of the Study:

  • To analyze the time trend incidence, identify risk factors, and evaluate the outcome of post-transplant lymphocele in a large pediatric cohort.
  • To determine specific pediatric risk factors for lymphocele development.

Main Methods:

  • Retrospective review of 241 pediatric kidney transplants performed between 2000 and 2013.
  • Analysis of various factors including recipient age, gender, transplant year, BMI, dialysis type, donor relation, acute rejection, and multiple transplantations.
  • Statistical analysis to associate these factors with lymphocele formation and graft survival.

Main Results:

  • The incidence of post-transplant lymphocele was 5.81% (14 out of 241 patients).
  • A significant reduction in lymphocele incidence was observed after 2006.
  • Identified risk factors for lymphocele included older age (≥11 years), male gender, BMI percentile for age ≥95%, and multiple transplantations.
  • One-year graft survival was significantly lower in patients who developed lymphocele (81.2% vs. 92.51%).

Conclusions:

  • Older age, male gender, high BMI, and multiple transplantations are significant risk factors for post-transplant lymphocele in children.
  • Post-transplant lymphocele is associated with reduced one-year graft survival in pediatric kidney transplant recipients.
  • This study highlights specific pediatric risk factors and the negative impact of lymphocele on graft outcomes.

Keywords:
kidneylymphocelepediatrictransplantation

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