Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

6.2K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.4K
1.4K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

6.1K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
6.1K
Apoptosis01:30

Apoptosis

11.9K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
11.9K
Cellular Injury V: Apoptosis and Autophagy01:22

Cellular Injury V: Apoptosis and Autophagy

71
Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
71

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacological modulation of ATF6: exploiting a stress-integrative node to overcome drug resistance.

Drug discovery today·2026
Same author

Sex- and stressor-dependent effects of metformin on cardiac fibrosis in plasminogen activator inhibitor-1 deficiency.

Journal of molecular and cellular cardiology·2026
Same author

A call to action for the use of composite hematologic measurements in hereditary hemorrhagic telangiectasia and other chronic bleeding disorders.

Expert review of hematology·2026
Same author

Suboptimal Responses to Anti-VEGF in Retinal Neurovascular Diseases: Linking Aging and Alternative Angioinflammatory Pathways.

Investigative ophthalmology & visual science·2026
Same author

Micro- and Nanoplastics in the Human Brain: Mechanistic Plausibility, Translational Challenges, and Links to Neurological Disease Trends.

Molecular neurobiology·2026
Same author

The precision revolution: Machine learning and the future of personalized therapy in hematologic malignancies.

European journal of pharmacology·2026

Related Experiment Video

Updated: Apr 25, 2026

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
19:44

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

18.2K

Apoptins: selective anticancer agents.

Oscar M Rollano Peñaloza1, Magdalena Lewandowska2, Joerg Stetefeld3

  • 1Department Clinical & Experimental Medicine, Division of Cell Biology, and Integrative Regenerative Medical Center, Linköping University, Linköping, Sweden; Instituto de Biologia Molecular y Biotecnologia, La Paz, Bolivia.

Trends in Molecular Medicine
|August 29, 2014
PubMed
Summary

Apoptin proteins show promise as a cancer therapy by selectively inducing cancer cell death. Research is ongoing to understand their mechanisms and develop effective delivery strategies for tumor treatment.

Keywords:
CDK2anaphase-promoting complexanticancer agentsprotein kinase Cprotein phosphatase 2A

More Related Videos

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

4.0K
Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics
12:28

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics

Published on: January 11, 2019

6.5K

Related Experiment Videos

Last Updated: Apr 25, 2026

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
19:44

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

18.2K
A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

4.0K
Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics
12:28

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics

Published on: January 11, 2019

6.5K

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Cancer therapies aim to selectively eliminate malignant cells while sparing healthy ones.
  • Apoptin proteins, originally from Chicken anemia virus (CAV), induce cancer cell apoptosis.
  • Human gyroviruses (HGyV) also possess apoptin-like proteins with conserved cancer-targeting activity.

Purpose of the Study:

  • To explore the potential of apoptin proteins as a novel cancer therapy.
  • To investigate the conserved functions and mechanisms of action of apoptin-like proteins from HGyV.
  • To develop strategies for effective apoptin delivery and dissemination within tumors.

Main Methods:

  • Investigating the cancer-selective apoptosis-inducing properties of apoptin proteins.
  • Analyzing the molecular mechanisms underlying apoptin's action in cancer cells.
  • Developing and evaluating preclinical delivery systems for apoptin-based cancer therapies.

Main Results:

  • Apoptin proteins demonstrate selective induction of apoptosis in cancer cells.
  • Apoptin-like proteins found in human gyroviruses share conserved tumor-targeting capabilities.
  • Preclinical studies show promise for apoptin delivery strategies in animal models.

Conclusions:

  • Apoptin proteins represent a promising therapeutic strategy for targeted cancer treatment.
  • Further research is needed to fully elucidate apoptin's mechanisms and optimize clinical application.
  • Developing effective delivery methods is crucial for realizing apoptin's therapeutic potential in oncology.