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Updated: Apr 25, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Coronary artery aneurysm occurring very late after drug-eluting stent implantation
Kenichi Okamura1, Yoshihiro Suematsu2, Sei Morizumi1
1Department of Cardiovascular Surgery, Tsukuba Memorial Hospital, Tsukuba-City, Ibaraki, Japan.
Insights
An 82-year-old woman developed late-onset coronary artery aneurysm after sirolimus-eluting stent implantation for myocardial infarction. Surgical repair with fibrin glue was successful, highlighting a rare complication and treatment approach.
Area of Science:
- Cardiology
- Interventional Cardiology
- Vascular Surgery
Background:
- Percutaneous coronary intervention with drug-eluting stents is a common treatment for coronary artery disease.
- Late complications after drug-eluting stent implantation are rare but can be serious.
Observation:
- An 82-year-old woman presented with recurrent angina eight years after sirolimus-eluting stent implantation.
- Coronary angiography revealed severe stenosis and a large aneurysm at the site of the previously implanted stent.
Findings:
- The patient underwent successful off-pump coronary artery bypass grafting with fibrin glue application to the coronary artery aneurysm.
- The postoperative course was uneventful, suggesting a viable surgical strategy for this rare complication.
Implications:
- This case highlights a rare late complication of sirolimus-eluting stents: coronary artery aneurysm formation.
- Surgical management, including coronary artery bypass grafting with aneurysm repair, can be effective for treating this rare entity when conservative measures fail.
Abstract:
An 82-year old woman presented with chest pain and was diagnosed as having acute myocardial infarction. Coronary angiography (CAG) showed 90% stenosis in the proximal left anterior descending artery (LAD). The patient underwent percutaneous coronary intervention using a sirolimus-eluting stent (SES). A repeat CAG performed 6 months after SES implantation revealed no problems. Eight years later, the patient presented with recurrent angina. CAG showed severe stenosis of the SES with a large aneurysm. We performed off-pump coronary artery bypass grafting without ligation or plication of the LAD, but with the application of fibrin glue to the coronary artery aneurysm. The postoperative course was uneventful. The mechanism responsible for the occurrence of coronary artery aneurysms occurring late after drug-eluting stent implantation remains unclear, and the treatment strategy remains controversial. Herein, we discuss a surgical treatment for this rare entity.
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