Jove
Visualize
Contact Us

Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.5K
The Parathyroid Glands00:59

The Parathyroid Glands

5.2K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
5.2K
Bone Disorders01:29

Bone Disorders

7.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
7.9K
Bone Remodeling01:40

Bone Remodeling

34.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.3K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

8.4K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
8.4K
What is the Skeletal System?01:02

What is the Skeletal System?

45.6K
Overview
45.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of heart failure on skeletal muscle: an overview.

Journal of geriatric cardiology : JGC·2026
Same author

Impact of abdominal adiposity correction on trabecular bone score (TBS) in obese women: A comparative study of software versions 3.0 and 4.0 with a predictive model.

Bone·2026
Same author

Can a consumer-grade bioimpedance device accurately estimate sarcopenia in women with type 2 diabetes? A cross-sectional agreement study with dual-energy X-ray absorptiometry.

Diabetes research and clinical practice·2025
Same author

Clinical outcomes of sutured scleral-fixated capsular tension segments in lens subluxation: a retrospective case series with short- and long-term follow-up.

International ophthalmology·2025
Same author

Myosteatosis and Type 2 Diabetes Mellitus.

Acta medica (Hradec Kralove)·2025
Same author

Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.

American heart journal plus : cardiology research and practice·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 25, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.5K

Bone disease in primary hyperparathyroidism.

Francisco Bandeira1, Natalie E Cusano2, Barbara C Silva3

  • 1Division of Endocrinology, Diabetes and Bone Diseases, Agamenon Magalhães Hospital, Brazilian Ministry of Health.

Arquivos Brasileiros De Endocrinologia E Metabologia
|August 29, 2014
PubMed
Summary
This summary is machine-generated.

Severe primary hyperparathyroidism (PHPT) causes osteitis fibrosa cystica (OFC), leading to bone pain and fractures. Bone mineral density loss in OFC is reversible with surgical treatment.

More Related Videos

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

17.1K
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

4.7K

Related Experiment Videos

Last Updated: Apr 25, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.5K
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

17.1K
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

4.7K

Area of Science:

  • Endocrinology
  • Orthopedics
  • Radiology

Background:

  • Severe primary hyperparathyroidism (PHPT) classically presents with osteitis fibrosa cystica (OFC), a bone disease.
  • OFC is characterized by bone pain, skeletal deformities, pathological fractures, and low bone mineral density.

Purpose of the Study:

  • To describe the clinical and radiographic features of bone disease in severe PHPT.
  • To highlight the reversibility of bone disease after surgical intervention.
  • To introduce newer technologies for assessing skeletal involvement in PHPT.

Main Methods:

  • Review of clinical manifestations including bone pain, fractures, muscle weakness, and neurological signs.
  • Radiographic analysis detailing diffuse demineralization, fractures, and characteristic bone lesions like brown tumors and cysts.
  • Mention of advanced imaging techniques such as Trabecular Bone Score (TBS) and high-resolution peripheral quantitative computed tomography (HR-pQCT).

Main Results:

  • Bone disease in PHPT includes salt-and-pepper skull, phalangeal erosions, brown tumors, and diffuse demineralization on radiography.
  • Pathological fractures commonly affect long bones.
  • Marked elevation of serum calcium and PTH, along with renal complications like nephrolithiasis, are observed in severe cases.

Conclusions:

  • Osteitis fibrosa cystica in severe PHPT leads to significant skeletal morbidity.
  • Bone disease and low bone mineral density are reversible following surgical cure of PHPT.
  • Emerging technologies like TBS and HR-pQCT offer enhanced insights into PHPT-related bone microarchitecture.