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Progressive, reversible sensorineural hearing loss caused by azathioprine
P W Jenkinson1, M I Syed1, L Mcclymont1
1Department of Otolaryngology,Raigmore Hospital,NHS Highlands,Inverness,Scotland,UK.
Objective:
This paper describes the first reported case of progressive sensorineural hearing loss caused by azathioprine, which was reversed on stoppage of the drug.
Case Report:
A female patient with previously normal hearing presented with progressive sensorineural hearing loss after being started on azathioprine. Otological and neurological examination findings were unremarkable. After stopping the drug, the patient reported an improvement in hearing, which was confirmed on pure tone audiometry.
Conclusion:
This previously unreported side effect of azathioprine is highlighted in order to increase clinical awareness. Early recognition of this adverse effect is important to minimise the possibility of permanent sensorineural hearing loss.
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