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Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
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Recombinant bovine interferon-gamma enhances expression of class I and class II bovine lymphocyte antigens

F Walrand1, F Picard, K McCullough

  • 1INRA, Ecole Nationale Vétérinaire, Alfort, France.

Veterinary Immunology and Immunopathology
|November 15, 1989
PubMed

Recombinant bovine interferon-gamma augments expression of class I and class II histocompatibility antigens on the surface membrane of bovine lymphocytes. Immunofluorescence techniques using a series of monoclonal anti-HLA antibodies demonstrate that this enhancement is detectable as early as 24 h after incubation with rBoIFN, while maximum surface expression is obtained within 3-5 days. A concentration as low as 10 units of rBoIFN is effective. Such results may be useful for characterizing the BoLA gene products.

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