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Updated: Apr 25, 2026

Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research
Published on: August 4, 2023
Improved reproducibility by assuring confidence in measurements in biomedical research
Anne L Plant1, Laurie E Locascio2, Willie E May3
1Biosystems and Biomaterials Division, Gaithersburg, Maryland, USA.
Abstract:
‘Irreproducibility’ is symptomatic of a broader challenge in measurement in biomedical research. From the US National Institute of Standards and Technology (NIST) perspective of rigorous metrology, reproducibility is only one aspect of establishing confidence in measurements. Appropriate controls, reference materials, statistics and informatics are required for a robust measurement process. Research is required to establish these tools for biological measurements, which will lead to greater confidence in research results.
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