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[Clock genes and circadian rhythm of blood pressure]

Koji Maemura

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |August 30, 2014
    PubMed

    Insights

    Cardiovascular function shows daily rhythms regulated by the internal biological clock. Disruptions to this circadian rhythm increase the risk of cardiovascular diseases like hypertension.

    Area of Science:

    • Cardiovascular physiology
    • Chronobiology
    • Molecular biology

    Context:

    • Circadian rhythms regulate physiological processes, including blood pressure and heart rate.
    • Mammalian clock genes form intricate feedback loops controlling biological clocks.
    • Shift work is linked to increased ischemic heart disease risk, highlighting circadian disruption's impact.

    Purpose:

    • To explore the relationship between the circadian clock and cardiovascular disease pathogenesis.
    • To understand the biological relevance of the internal clock in cardiovascular health.

    Summary:

    • Cardiovascular functions exhibit circadian oscillations regulated by molecular clock genes.
    • Disrupting the circadian rhythm in mice models is linked to cardiovascular diseases, including hypertension.
    • Shift work is associated with higher risks of ischemic heart disease.

    Impact:

    • Findings may lead to novel chronotherapeutic strategies for cardiovascular disease prevention and treatment.
    • Understanding the internal clock's role offers new avenues for managing hypertension and other cardiovascular conditions.

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