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Related Concept Videos

Asthma I: Introduction01:28

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Related Experiment Video

Updated: Apr 25, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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[The research for atopic dermatitis: up to date].

Hiroo Yokozeki

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |August 30, 2014
    PubMed
    Summary

    Atopic dermatitis involves complex interactions between skin barrier defects and immune responses. Filaggrin gene mutations worsen barrier function, promoting allergic reactions and disease progression.

    Area of Science:

    • Dermatology
    • Immunology
    • Genetics

    Background:

    • Atopic dermatitis (AD) is a prevalent allergic skin condition with a complex, heterogeneous pathogenesis.
    • Key factors include non-allergic elements like skin barrier dysfunctions and allergic components.
    • Filaggrin gene mutations are recognized as significant contributors to skin barrier dysfunction in AD.

    Purpose of the Study:

    • To review the intricate interplay between skin barrier abnormalities and immune dysregulation in atopic dermatitis pathogenesis.
    • To elucidate the relationship between non-allergic and allergic factors in AD development.

    Main Methods:

    • Literature review focusing on the pathogenesis of atopic dermatitis.
    • Analysis of the interaction between skin barrier function, filaggrin gene mutations, and immune responses (Th1/Th2).

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    Main Results:

    • Skin barrier dysfunction, particularly due to filaggrin gene mutations, is a critical factor in AD.
    • Barrier defects promote a shift from Th1 to Th2 immune responses.
    • Th2 cytokines further impair skin barrier function by reducing filaggrin expression.

    Conclusions:

    • A complex interplay exists between skin barrier abnormalities and immune dysregulation in AD pathogenesis.
    • Non-allergic and allergic factors are closely interconnected, driving disease progression.
    • Understanding this interplay is crucial for developing effective AD treatments.