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Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
Published on: November 1, 2024
470
Helicobacter pylori and extragastric diseases
Francesco Franceschi1, Annalisa Tortora, Giovanni Gasbarrini
1Internal Medicine Institute, Catholic University of Rome, Rome, Italy.
Helicobacter
|August 30, 2014
Summary
Helicobacter pylori infection is linked to more than just stomach issues, potentially impacting various extragastric conditions. This review explores the latest research on H. pylori
Area of Science:
- Gastroenterology and Infectious Diseases
- Microbiology
- Immunology
Background:
- Helicobacter pylori (H. pylori) infection was initially associated with gastroduodenal diseases.
- Emerging evidence suggests H. pylori plays a role in extragastric conditions.
- The mechanisms linking H. pylori to these diseases are under investigation.
Purpose of the Study:
- To review recent studies on the extragastric manifestations of H. pylori infection.
- To summarize the proposed mechanisms of H. pylori's influence on non-gastroduodenal diseases.
- To highlight the potential role of H. pylori in conditions beyond the gastrointestinal tract.
Main Methods:
- Literature review of studies published within the last year.
- Synthesis of findings on H. pylori's association with various extragastric diseases.
- Analysis of proposed pathogenic mechanisms.
Main Results:
- H. pylori infection is recommended for diagnosis in idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency.
- Potential roles for H. pylori are identified in cardiovascular, neurological, dermatological, and respiratory diseases.
- A possible link between H. pylori and gastrointestinal cancers, including colorectal and pancreatic cancer, is noted.
Conclusions:
- H. pylori infection extends beyond gastroduodenal pathologies.
- The bacterium may contribute to a range of extragastric diseases through inflammatory or molecular mimicry pathways.
- Further research is warranted to elucidate the full spectrum of H. pylori's impact.
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