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MicroRNAs and p63 in epithelial stemness

E Candi1, I Amelio2, M Agostini2

  • 11] Biochemistry Laboratory, IDI-IRCCS, Rome 00133, Italy [2] Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome 00133, Italy.

Cell Death and Differentiation
|August 30, 2014
PubMed

Insights

MicroRNAs (miRs) regulate epidermal stem cell biology by interacting with the p63 transcription factor. This interaction controls gene expression, impacting cell fate and homeostasis, with potential therapeutic applications.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Stem Cell Biology

Background:

  • MicroRNAs (miRs) are small noncoding RNAs that regulate gene expression.
  • The p63 transcription factor is crucial for epidermal development and homeostasis.
  • The interplay between miRs and p63 in epithelial stem cells is vital but not fully understood.

Purpose of the Study:

  • To review recent findings on the miR-p63 interaction in epidermal biology.
  • To highlight the role of p63 in regulating miR processing components like DGCR8.
  • To discuss discrepancies and explore therapeutic opportunities related to this interaction.

Main Methods:

  • Literature review of recent studies on miR-p63 interactions.
  • Focus on findings from ΔNp63(-/-) mouse models.
  • Analysis of p63's direct and indirect regulation of miR expression and processing.

Main Results:

  • p63 directly regulates the transcription of several miRs.
  • p63 indirectly influences miR processing by controlling Dicer and DGCR8 expression.
  • Recent studies reveal ΔNp63-dependent regulation of DGCR8 in specific mouse models.

Conclusions:

  • The reciprocal interaction between miRs and p63 is fundamental to epidermal stem cell regulation.
  • Understanding this interplay offers insights into keratinocyte fate, differentiation, and senescence.
  • This knowledge may pave the way for novel therapeutic strategies in skin biology.

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