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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Stem Cell Biology

Background:

  • MicroRNAs (miRs) are small noncoding RNAs that regulate gene expression.
  • The p63 transcription factor is crucial for epidermal development and homeostasis.
  • The interplay between miRs and p63 in epithelial stem cells is vital but not fully understood.

Purpose of the Study:

  • To review recent findings on the miR-p63 interaction in epidermal biology.
  • To highlight the role of p63 in regulating miR processing components like DGCR8.
  • To discuss discrepancies and explore therapeutic opportunities related to this interaction.

Main Methods:

  • Literature review of recent studies on miR-p63 interactions.
  • Focus on findings from ΔNp63(-/-) mouse models.
  • Analysis of p63's direct and indirect regulation of miR expression and processing.

Main Results:

  • p63 directly regulates the transcription of several miRs.
  • p63 indirectly influences miR processing by controlling Dicer and DGCR8 expression.
  • Recent studies reveal ΔNp63-dependent regulation of DGCR8 in specific mouse models.

Conclusions:

  • The reciprocal interaction between miRs and p63 is fundamental to epidermal stem cell regulation.
  • Understanding this interplay offers insights into keratinocyte fate, differentiation, and senescence.
  • This knowledge may pave the way for novel therapeutic strategies in skin biology.