Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Blood vessel-associated inflammatory microglia and astrocytes are associated with molecular and cellular markers of blood-brain barrier permeability in neonatal mice infected with the respiratory pathogen Bordetella pertussis.

Journal of neuroinflammation·2026

Same author

Neuropharmacology - VSI: Microglia (Editorial).

Neuropharmacology·2025

Same author

Neonatal infection with <i>Bordetella pertussis</i> promotes autism-like phenotypes in mice.

iScience·2025

Same author

A case for seeking sex-specific treatments in Alzheimer's disease.

Frontiers in aging neuroscience·2024

Same author

Acute Stress, Induced by IFNγ + Aβ, and Chronic Stress, Induced by Age, Affect Microglia in a Sex-Specific Manner.

Molecular neurobiology·2023

Same author

Sex-Related Microglial Perturbation Is Related to Mitochondrial Changes in a Model of Alzheimer's Disease.

Frontiers in cellular neuroscience·2022

Search research articles

Related Experiment Video

Updated: Apr 25, 2026

Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology

Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology

Published on: May 31, 2024

How dependent is synaptic plasticity on microglial phenotype?

Raasay S Jones¹, Marina A Lynch¹

¹Trinity College Institute of Neuroscience, Department of Physiology, Trinity College, Dublin 2, Ireland.

Neuropharmacology

|August 30, 2014

Summary

This summary is machine-generated.

Microglia, immune cells in the brain, can adopt different states. In neurodegenerative diseases like Alzheimer's disease (AD), pro-inflammatory microglia may worsen neuronal damage.

Keywords:

Age Alzheimer's disease Astrocytes Inflammatory cytokines Microglia Neuroinflammation Neuronal function

More Related Videos

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

Published on: July 26, 2024

Related Experiment Videos

Last Updated: Apr 25, 2026

Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology

Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology

Published on: May 31, 2024

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

Published on: July 26, 2024

Area of Science:

Neuroimmunology
Cellular Biology
Neurodegeneration

Background:

Microglia are brain-resident immune cells with high plasticity.
They maintain homeostasis and perform surveillance in a resting state.
Upon activation, microglia adopt either neuroprotective (anti-inflammatory) or neurodetrimental (pro-inflammatory) phenotypes.

Purpose of the Study:

To review the role of microglia in neurodegenerative diseases.
Specifically focusing on their pro-inflammatory phenotype in Alzheimer's disease (AD) animal models.

Main Methods:

This review synthesizes existing evidence from scientific literature.
Focuses on studies utilizing animal models of neurodegeneration, particularly AD.

Main Results:

Activated microglia with a pro-inflammatory phenotype are prevalent in neurodegenerative conditions.
This pro-inflammatory state is implicated in the decline of neuronal function observed in these diseases.

Conclusions:

The pro-inflammatory activation of microglia is a significant factor in the pathogenesis of neurodegenerative diseases like AD.
Understanding microglial plasticity is crucial for developing therapeutic strategies targeting neuroinflammation.