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Symptomatology and pathogenesis of different types of pain in multiple sclerosis

Waldemar Brola1, Krystyna Mitosek-Szewczyk2, Józef Opara3

  • 1Department of Neurology with Stroke Unit, Specialist Hospital, Końskie, Poland.

Neurologia I Neurochirurgia Polska
|August 30, 2014
PubMed

Insights

Pain is a common and debilitating symptom in multiple sclerosis (MS), affecting up to 86% of patients. Understanding its mechanisms and effective treatments is crucial for improving quality of life.

Area of Science:

  • Neurology
  • Neuroscience
  • Pain Medicine

Background:

  • Multiple sclerosis (MS) is a progressive central nervous system disease characterized by demyelination.
  • Pain is a frequent and underestimated symptom in MS, impacting quality of life and rehabilitation.
  • Pain in MS significantly affects 29-86% of patients across disease stages.

Purpose of the Study:

  • To explore the mechanisms, prevalence, and classification of pain in multiple sclerosis.
  • To identify and discuss the most effective treatment strategies for MS-related pain.
  • To provide a comprehensive overview of pain as a symptom in multiple sclerosis.

Main Methods:

  • Literature review of studies on pain mechanisms in MS.
  • Analysis of pain prevalence data in multiple sclerosis populations.
  • Classification of different pain types experienced by MS patients.

Main Results:

  • Pain in MS is primarily central neuropathic, stemming from nervous system damage.
  • Common pain manifestations include dysesthetic extremity pain, spasms, Lhermitte's sign, trigeminal neuralgia, headaches, and low back pain.
  • Pain significantly impacts patient rehabilitation and overall quality of life.

Conclusions:

  • Pain is a complex and prevalent symptom in multiple sclerosis requiring focused management.
  • Effective treatment strategies are essential for alleviating pain and improving patient outcomes in MS.
  • Further research into MS pain mechanisms and treatments is warranted.
Keywords:
Chronic painHealth-related quality of lifeMultiple sclerosisNeuropathic pain

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