Micro- and nanotechnologies for intracellular delivery

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Drug Delivery

Background:

• Cell membranes pose a significant barrier to intracellular drug and biomolecule delivery.
• Reduced intracellular delivery efficiency limits therapeutic effectiveness.
• Various chemical and physical methods are being developed to overcome cellular barriers.

Purpose of the Study:

• To review nanomaterial-based strategies for targeted intracellular delivery.
• To summarize physical methods utilizing micro- and nanotechnologies for high-throughput intracellular delivery.

Main Methods:

• Focus on nanomaterial routes employing cell receptors for targeted delivery.
• Discussion of physical methods using micro- and nanotechnologies.
• Review of approaches for enhancing intracellular drug and biomolecule transport.

Main Results:

• Nanomaterials can be engineered to target specific cell receptors for enhanced uptake.
• Micro- and nanotechnologies offer efficient physical routes for intracellular delivery.
• These strategies significantly improve the efficiency of getting drugs and biomolecules into cells.

Conclusions:

• Targeted delivery using nanomaterials and receptor interactions is a promising approach.
• Physical methods involving micro/nanotechnology enable high-throughput intracellular delivery.
• Overcoming cell membrane barriers is crucial for effective intracellular therapeutics.