Related Experiment Video
Updated: Apr 25, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Prescriptions for dietary sodium in patients with chronic kidney disease: how will this shake out?
John P Middleton1, Ruediger W Lehrich1
1Division of Nephrology, Duke University, Durham, North Carolina, USA.
Abstract:
Patients with chronic kidney disease (CKD) are at risk of exhibiting expanded extracellular volume, and low-sodium diets are often prescribed to limit clinical complications from this condition. Fan et al. performed a post hoc study from the database of the Modification of Diet in Renal Disease Study. Their article, as well as other recent observations, suggests that a low-sodium diet may not be as beneficial as previously thought in all CKD patients.
Related Concept Videos
Chronic Kidney Disease III: Interprofessional Care
Acute Kidney Injury VI: Nursing Management
Chronic Kidney Disease IV: Nursing Management
Nephrotic Syndrome III : Nursing Management
Heart Failure VI: Adjunct Therapies
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

