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Related Concept Videos

Phosphate Buffer01:22

Phosphate Buffer

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The phosphate buffer system is a critical biological mechanism for maintaining pH stability in the body. This system operates primarily through two components: sodium dihydrogen phosphate (NaH2PO4), which acts as a weak acid, and sodium hydrogen phosphate (Na2HPO4), which serves as a weak base.
Sodium dihydrogen phosphate does not fully dissociate in neutral or acidic solutions. When a strong base, such as sodium hydroxide (NaOH), is introduced into the solution, sodium dihydrogen phosphate...
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Roles of Electrolytes: Calcium and Phosphate01:27

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Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
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Unlike carbon, water, and nitrogen, phosphorus is not present in the atmosphere as a gas. Instead, most phosphorus in the ecosystem exists as compounds, such as phosphate ions (PO43-), found in soil, water, sediment and rocks. Phosphorus is often a limiting nutrient (i.e., in short supply). Consequently, phosphorus is added to most agricultural fertilizers, which can cause environmental problems related to runoff in aquatic ecosystems.
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Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
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Introduction to Electrolytes01:33

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In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
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Phosphorylation01:02

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The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
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Related Experiment Video

Updated: Apr 25, 2026

Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method
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Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method

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Novel phosphate binders: plus ça change, plus c'est la même chose.

Alastair J Hutchison1

  • 1Manchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

Kidney International
|August 30, 2014
PubMed
Summary

New sucroferric oxyhydroxide effectively controls phosphate levels with fewer pills than sevelamer. This reduced pill burden may improve patient adherence, though clinical outcome benefits require further study.

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Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method
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Area of Science:

  • Nephrology
  • Pharmacology
  • Biochemistry

Background:

  • Hyperphosphatemia is a common complication in chronic kidney disease.
  • Oral phosphate binders are essential for managing serum phosphate levels.
  • Current binders like sevelamer can have a high pill burden, impacting adherence.

Purpose of the Study:

  • To evaluate the efficacy of sucroferric oxyhydroxide as a novel phosphate binder.
  • To compare phosphate control and pill burden with sevelamer.
  • To assess the potential impact of reduced pill burden on patient adherence.

Main Methods:

  • A study compared sucroferric oxyhydroxide to sevelamer for phosphate control.
  • Dosage and patient adherence were key metrics.
  • Ligand exchange mechanism of sucroferric oxyhydroxide was noted.

Main Results:

  • Sucroferric oxyhydroxide demonstrated equivalent phosphate control to sevelamer.
  • The mean daily dose was significantly lower for sucroferric oxyhydroxide (three pills) versus sevelamer (eight pills).
  • A reduced pill burden was suggested as a potential aid to improved adherence.

Conclusions:

  • Sucroferric oxyhydroxide offers an effective alternative for phosphate binding.
  • Lowering the pill burden may enhance patient adherence to treatment.
  • Prospective studies are needed to confirm if reduced serum phosphate improves patient outcomes.