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An association between BDNF Val66Met polymorphism and impulsivity in methamphetamine abusers.

Hang Su1, Jingyan Tao1, Jie Zhang1

  • 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Neuroscience Letters
|August 30, 2014
PubMed
Summary

The BDNF Val66Met gene polymorphism is linked to higher attentional impulsivity and earlier onset of methamphetamine use in abusers. This genetic factor may influence addiction vulnerability.

Keywords:
AssociationBrain-derived neurotrophic factorGenotypeImpulsivityMethamphetamine

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • A functional polymorphism in the BDNF gene (Val66Met) has been associated with susceptibility to methamphetamine addiction.
  • This study investigates the link between the BDNF Val66Met polymorphism, methamphetamine abuse, and impulsivity.

Purpose of the Study:

  • To examine the association of the BDNF Val66Met polymorphism with methamphetamine abuse and impulsivity.
  • To explore the relationship between this polymorphism and the age of onset of methamphetamine abuse.

Main Methods:

  • Genotyping of the BDNF Val66Met polymorphism in 200 methamphetamine abusers and 219 healthy controls.
  • Assessment of impulsivity using the Barratt Impulsivity Scale-11 (BIS-11) in 138 methamphetamine abusers.
  • Analysis of genotype and allele distributions and their correlation with impulsivity and age of onset.

Main Results:

  • No significant differences in genotype or allele frequencies were found between methamphetamine abusers and controls.
  • Within the methamphetamine-abuse group, carriers of the Met allele exhibited significantly higher attentional impulsivity scores compared to the Val/Val genotype.
  • The Met allele was associated with an earlier age of onset for methamphetamine use.

Conclusions:

  • The BDNF Val66Met gene polymorphism may influence attentional impulsivity in individuals with methamphetamine abuse.
  • This genetic polymorphism might play a role in determining the age of onset for methamphetamine use, suggesting a potential genetic predisposition.