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PubChem applications in drug discovery: a bibliometric analysis
Tiejun Cheng1, Yongmei Pan1, Ming Hao1
1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA.
Drug Discovery Today
|August 30, 2014
Summary
This bibliometric analysis reveals PubChem
Area of Science:
- * Cheminformatics and Chemical Biology
- * Medicinal Chemistry and Drug Discovery
- * Bioinformatics and Computational Biology
Background:
- * PubChem is a vast public repository of chemical structures and bioactivity data.
- * Its online services are utilized globally across diverse scientific disciplines.
- * The resource supports critical aspects of modern drug discovery and development.
Purpose of the Study:
- * To conduct a bibliometric analysis of PubChem applications.
- * To review 1132 research articles to understand PubChem's impact.
- * To highlight PubChem's role in advancing chemical biology, medicinal chemistry, and informatics.
Main Methods:
- * Bibliometric analysis of 1132 research articles.
- * Review of publications citing PubChem applications.
- * Synthesis of findings on PubChem's utility and impact.
Main Results:
- * PubChem is extensively used in chemical biology, medicinal chemistry, and informatics.
- * It significantly aids drug discovery processes like lead identification, optimization, and target profiling.
- * PubChem is instrumental in developing secondary databases, informatics tools, and web services.
Conclusions:
- * PubChem is a vital, globally utilized resource for chemical and biological data.
- * Its public availability fosters drug innovation, repurposing, and understanding disease mechanisms.
- * The platform offers significant opportunities for pharmacological and genetic research.
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