Ureteral metastasis from prostate cancer

Area of Science:

• Oncology
• Urology

Background:

• A 59-year-old man presented with elevated prostate-specific antigen (PSA), diagnosed with advanced prostatic adenocarcinoma with bone and lymph node metastases.
• Initial treatment with combined androgen blockade therapy led to a temporary PSA reduction.

Observation:

• The patient progressed to castration-resistant prostate cancer, treated with docetaxel chemotherapy.
• Radiological findings revealed left hydronephrosis and a left lower ureteral tumor, initially suspected as urothelial carcinoma.

Findings:

• Pathological examination of the resected ureteral mass post-nephroureterectomy confirmed metastatic prostate carcinoma.
• Serum PSA levels decreased post-operatively from 59.56 to 45.33 ng/mL.

Implications:

• This case highlights the importance of comprehensive pathological evaluation in complex oncological presentations.
• Accurate diagnosis of metastatic disease is crucial for appropriate treatment and patient management in advanced prostate cancer.