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Serum Endocan Level and the Severity of Coronary Artery Disease: A Pilot Study

Murat Kose1, Samim Emet2, Timur Selcuk Akpinar1

  • 1Department of Internal Medicine, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.

Angiology
|August 30, 2014
PubMed

Insights

Serum endocan levels are significantly elevated in patients with acute coronary syndrome (ACS), indicating its potential as a biomarker for endothelial dysfunction in this condition.

Area of Science:

  • Cardiology
  • Biomarkers
  • Endothelial Biology

Background:

  • Endothelial-specific molecule 1 (endocan) is a proteoglycan primarily expressed in endothelial cells.
  • Endothelial dysfunction plays a critical role in the pathophysiology of acute coronary syndrome (ACS).

Purpose of the Study:

  • To investigate the association between serum endocan levels and the presence and characteristics of ACS.
  • To evaluate endocan as a potential biomarker for endothelial pathology in ACS patients.

Main Methods:

  • A case-control study involving 53 patients with ACS and 30 healthy controls.
  • Serum endocan levels were measured and compared between groups.
  • Coronary artery disease severity was assessed using Gensini and SYNTAX scores.

Main Results:

  • Serum endocan levels were significantly higher in the ACS group compared to the control group (P = .014).
  • Diabetic patients with ACS exhibited higher serum endocan levels than non-diabetic ACS patients (P = .016).
  • No significant correlation was found between serum endocan levels and Gensini or SYNTAX scores.

Conclusions:

  • Serum endocan levels are significantly elevated in patients with ACS, suggesting its role as a marker of endothelial pathology.
  • Endocan may serve as a novel biomarker for identifying endothelial dysfunction in the context of ACS.
  • Further research is warranted to explore the clinical utility of endocan in ACS management.

Keywords:
Gensini scoreSYNTAX scoreacute coronary syndromecoronary artery diseaseendocanendothelial-specific molecule 1

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