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Updated: Apr 25, 2026
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Published on: July 28, 2010
Expression of cyclooxygenase-2 (COX-2) in colorectal adenocarcinoma: an immunohistochemical and histopathological
Abla Sayed Mahmoud1, Ayesha Umair, Saleh Nasser Azzeghaiby
1Department of Oral Maxillofacial Sciences, Alfarabi College of Dentistry Alfarabi, Kingdom of Saudi Arabia
Background:
The aim of this study was to evaluate cyclooxygenase-2 (COX-2) immunoreactivity in colorectal adenocarcinomas and to find correlations with different pathological features.
Materials And Methods:
This study included 35 cases of colorectal carcinoma for which surgical colectomy specimens were collected. Immunohistochemical staining of COX-2 (cyclooxygenase-2) is done by using the Streptavidin-biotin technique.
Results:
This work reveals that COX-2 is positive in most cases of colorectal carcinoma and negative in normal colon tissue with statistically non significant relations between COX-2 immunostaining and different pathological features.
Conclusions:
Our data suggest overexpression of COX-2 protein in colorectal carcinoma in contrast to normal mucosa, with a possible role in cell proliferation in carcinogenesis.
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