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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

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Concomitant Kaposi sarcoma and multicentric Castleman's disease in a heart transplant recipient

Ami Patel1, Eliahu Bishburg1, Mark Zucker1

  • 1Newark Beth Israel Medical Center, 201 Lyons Avenue, Newark, NJ 07112, USA.

Heart & Lung : the Journal of Critical Care
|August 30, 2014
PubMed

Insights

Post-transplant human herpes virus-8 (HHV-8) infection can cause Kaposi sarcoma (KS) and multicentric Castleman

Area of Science:

  • Infectious Diseases
  • Oncology
  • Transplantation Medicine

Background:

  • Post-transplant human herpes virus-8 (HHV-8), also known as Kaposi sarcoma herpes virus (KSHV), is linked to various diseases in solid organ transplant (SOT) recipients.
  • Common HHV-8-associated neoplastic complications include Kaposi sarcoma (KS), multicentric Castleman's disease (MCD), and primary effusion lymphomas (PEL).

Observation:

  • Concurrent KS and MCD have been rarely reported post-transplantation, with only two previous cases documented after liver and renal transplants.
  • This report details a unique case of a heart transplant recipient who developed concurrent KS and MCD.

Findings:

  • This is the first documented instance of a heart transplant recipient presenting with simultaneous KS and MCD.
  • The case highlights the potential for concurrent HHV-8-mediated complications in heart transplant recipients.

Implications:

  • This case expands the understanding of HHV-8-associated complications in SOT recipients.
  • Early recognition and management of concurrent KS and MCD are crucial in heart transplant patients.
  • Further research into HHV-8 pathogenesis and management in transplant populations is warranted.

Keywords:
HHV-8Heart transplantKSMCD

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