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The chromatography technique was first invented in 1901 by Michael S. Tswett, a Russian botanist, to separate plant pigments using organic solvents. Further, in 1941, Archer John Porter Martin and R. L. M. Synge modified the technique by packing silica gel into a column. A mixture of amino acids was then separated on the packed column using chloroform and water mixture as the mobile phase. This was the first report on column chromatography. At present, column chromatography is a widely used...
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Three column intermittent simulated moving bed chromatography: 1. Process description and comparative assessment.

Simon Jermann1, Marco Mazzotti1

  • 1Institute of Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092 Zurich, Switzerland.

Journal of Chromatography. A
|August 30, 2014
PubMed
Summary

A new three-column intermittent simulated moving bed (3C-ISMB) process enhances binary separations. This chromatography method increases productivity by 60% using fewer columns than conventional I-SMB.

Keywords:
3C-ISMBI-SMBSeparation of enantiomersSimulated moving bed chromatographyThree-zone SMB

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Area of Science:

  • Chemical Engineering
  • Chromatography

Background:

  • Simulated Moving Bed (SMB) chromatography is a key industrial separation technique.
  • Conventional I-SMB processes utilize four columns for binary separations.
  • Optimizing SMB processes for higher throughput and efficiency is an ongoing challenge.

Purpose of the Study:

  • To introduce and analyze a novel three-column intermittent simulated moving bed (3C-ISMB) process.
  • To evaluate the performance of 3C-ISMB in terms of productivity, column count, and solvent consumption.
  • To demonstrate the design feasibility of 3C-ISMB using established methods like Triangle Theory.

Main Methods:

  • Detailed description of the 3C-ISMB process concept, including intermittent feeding, product withdrawal, and internal recycling.
  • Extensive simulation study to analyze the cyclic steady-state behavior of the 3C-ISMB process.
  • Application of Triangle Theory for process design, even under non-linear chromatographic conditions.

Main Results:

  • The 3C-ISMB process enables binary separations using only three columns, compared to four in conventional I-SMB.
  • Higher internal flow rates are achievable due to fewer columns, leading to increased throughput.
  • Simulation results indicate a productivity increase of approximately 60% compared to conventional I-SMB, with comparable solvent consumption.

Conclusions:

  • The 3C-ISMB process offers a significant advancement in chromatographic separations, achieving higher productivity with fewer columns.
  • The process is amenable to straightforward design using Triangle Theory, simplifying implementation.
  • 3C-ISMB presents a superior alternative to conventional I-SMB for efficient binary separations.