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RNA Editing

RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...

Proofreading

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Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore, it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase...

Proofreading

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CRISPR

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...

CRISPR/Cas9 Genome Editing

CRISPR/Cas9 Genome Editing

The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...

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Related Experiment Video

Updated: Apr 25, 2026

CRISPR/Cas9 Editing of the C. elegans rbm-3.2 Gene using the dpy-10 Co-CRISPR Screening Marker and Assembled Ribonucleoprotein Complexes.

CRISPR/Cas9 Editing of the C. elegans rbm-3.2 Gene using the dpy-10 Co-CRISPR Screening Marker and Assembled Ribonucleoprotein Complexes.

Published on: December 11, 2020

So you think you can edit?

Priya Prakash Budde¹

¹Reviews Editor, The Journal of Cell Biology, Rockefeller University Press, New York, NY 10065 pbudde@rockefeller.edu.

Molecular Biology of the Cell

|August 30, 2014

Summary

This summary is machine-generated.

This article explores the career shift from hands-on scientific research to scientific editing. It offers insights into the skills and experiences valuable for this transition.

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Area of Science:

Scientific publishing
Academic careers

Background:

The traditional scientific career path often involves extensive laboratory research.
Transitioning to alternative careers, such as scientific editing, is becoming more common for scientists.

Purpose of the Study:

To provide a personal perspective on the transition from bench science to an editorial role.
To highlight the transferable skills and unique insights gained from a research background.

Main Methods:

Personal narrative and reflection.
Analysis of the author's own career trajectory.

Main Results:

The skills developed in scientific research (e.g., critical evaluation, attention to detail) are highly applicable to editorial work.
An editorial career offers a different yet equally valuable way to contribute to the scientific community.

Conclusions:

The transition from bench to editorial work is feasible and rewarding.
Scientists possess a strong foundation for success in scientific editing.