Related Experiment Video

Updated: Apr 25, 2026

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
08:57

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Published on: March 26, 2015

29.7K

Double inversion recovery sequence of the cervical spinal cord in multiple sclerosis and related inflammatory

I Riederer1, D C Karampinos2, M Settles2

  • 1From the Departments of Diagnostic and Interventional Neuroradiology (I.R., C.P., J.S.B., J.F.K., C.Z.) Isabelle.riederer@tum.de.

AJNR. American Journal of Neuroradiology
|August 30, 2014
PubMed
Abstract

Insights

A new 3D double inversion recovery MRI sequence significantly improves the detection of inflammatory lesions in the cervical spinal cord for multiple sclerosis (MS) patients. This advanced technique offers higher sensitivity and better lesion visibility than conventional 2D T2-weighted imaging.

Area of Science:

  • Radiology
  • Neuroimaging
  • Medical Physics

Background:

  • Magnetic Resonance (MR) imaging is crucial for diagnosing multiple sclerosis (MS) and related inflammatory conditions.
  • Spinal cord imaging, particularly in the cervical region, presents significant challenges for accurate lesion detection.

Purpose of the Study:

  • To evaluate the sensitivity of a novel 3D double inversion recovery (DIR) sequence for cervical spinal cord imaging.
  • To compare the diagnostic performance of 3D DIR with conventional 2D T2-weighted turbo spin-echo (TSE) sequences at 3 Tesla (3T).

Main Methods:

  • Acquisition of cervical spinal cord images using both 3D DIR and conventional 2D T2-weighted TSE sequences on a 3T MR scanner.
  • Inclusion of 30 patients with suspected/established MS and 10 healthy controls.
  • Independent assessment of lesion numbers, visibility, and image quality by two blinded neuroradiologists.

Main Results:

  • The 3D DIR sequence detected 28% more lesions compared to conventional T2WI (119 vs. 93 lesions; P < .002).
  • Significantly higher standardized contrast-to-noise ratios (P < .001) were observed with 3D DIR.
  • Lesion visibility was rated significantly higher (P < .001) with 3D DIR, despite slightly lower overall image quality.

Conclusions:

  • The novel 3D DIR sequence demonstrates superior capability in detecting inflammatory lesions in the cervical spinal cord.
  • This advanced MR imaging technique offers improved diagnostic sensitivity for MS and related inflammatory diseases compared to conventional 2D T2WI.

More Related Videos

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury10:49

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury

Published on: September 18, 2011

20.2K
Two-photon Imaging of Cellular Dynamics in the Mouse Spinal Cord10:44

Two-photon Imaging of Cellular Dynamics in the Mouse Spinal Cord

Published on: February 22, 2015

9.9K

Related Concept Videos

Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
34
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
14
Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
14
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
5.5K