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[Antiseptic sensitivity of clinical strains of Pseudomonas aeruginosa]
Abstract:
MICs, the frequency of clinical and statistic resistance and the antiseptic activity index were studied in complex on out-of-hospital and hospital ecovars of P. aeruginosa. The forms resistant to a number of antiseptics, i.e. chloramine B, chlorhexidine, decamethoxine and dioxidine whose frequency eventually increased were shown to be widely distributed. The antiseptic sensitivity spectrum was more narrow and more heterogeneous than that of other bacteria, the heterogeneity level being dependent on the antiseptic type and bacterial ecovar. The activity of pervomur, phenol, resorcin and boric acid was higher against the clinical strains of P. aeruginosa while iodopyrin, sulfacetamide sodium and dioxidine were less active. The P. aeruginosa strains had natural resistance to cetylpyridinium chloride, rokkal, ethonium, sodium laurate and laurylsulfate and rivanol. It was recommended to assay antiseptic sensitivity of agents causing purulent inflammatory infections and to control circulation of antiseptic resistant variants of bacteria in hospitals.
Insights
Pseudomonas aeruginosa exhibits increasing resistance to common antiseptics like chloramine B and chlorhexidine. Hospitals should monitor antiseptic-resistant bacteria to prevent infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Pseudomonas aeruginosa is an opportunistic pathogen frequently associated with hospital-acquired infections.
- The emergence of antiseptic-resistant bacterial strains poses a significant challenge to infection control.
- Understanding the resistance patterns of P. aeruginosa to various antiseptics is crucial for effective treatment and prevention.
Purpose of the Study:
- To investigate the minimum inhibitory concentrations (MICs) and antiseptic activity index of P. aeruginosa against a range of antiseptics.
- To determine the prevalence of antiseptic-resistant P. aeruginosa ecovars in both hospital and out-of-hospital settings.
- To assess the spectrum and heterogeneity of antiseptic sensitivity in clinical P. aeruginosa strains.
Main Methods:
- Minimum Inhibitory Concentrations (MICs) determination.
- Antiseptic activity index calculation.
- Comparative analysis of antiseptic sensitivity across different P. aeruginosa ecovars and clinical strains.
Main Results:
- Widespread distribution of P. aeruginosa strains resistant to chloramine B, chlorhexidine, decamethoxine, and dioxidine, with increasing frequency.
- A narrower and more heterogeneous antiseptic sensitivity spectrum in P. aeruginosa compared to other bacteria, varying by antiseptic and ecovar.
- Higher activity of pervomur, phenol, resorcin, and boric acid against clinical P. aeruginosa strains; lower activity of iodopyrin, sulfacetamide sodium, and dioxidine.
- Inherent resistance of P. aeruginosa to cetylpyridinium chloride, rokkal, ethonium, sodium laurate, laurylsulfate, and rivanol.
Conclusions:
- Clinical and hospital P. aeruginosa strains show significant and increasing resistance to several commonly used antiseptics.
- Antiseptic sensitivity testing for agents causing purulent infections is recommended.
- Continuous monitoring of antiseptic-resistant bacterial variants in hospital environments is essential for infection control.