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Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
649
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

866
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
866
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

665
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
665
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

654
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
654
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

609
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
609
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

755
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Related Experiment Video

Updated: Apr 25, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
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Arterial stiffness and cardiovascular therapy.

Miodrag Janić1, Mojca Lunder1, Mišo Sabovič1

  • 1Department of Vascular Diseases, University of Ljubljana Medical Centre, Zaloška 7, SI 1000 Ljubljana, Slovenia.

Biomed Research International
|August 30, 2014
PubMed
Summary

Arterial stiffening is a common aging issue. This review surveys drugs that may reduce arterial stiffness, aiding cardiovascular disease prevention, though more research is needed.

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Area of Science:

  • Gerontology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Global populations are aging, leading to increased prevalence of age-related arterial stiffening.
  • Arterial stiffness, measured by pulse wave velocity (PWV), is a key indicator of cardiovascular risk.
  • PWV can enhance prediction of cardiovascular events beyond traditional risk factors.

Purpose of the Study:

  • To review pharmacological therapies aimed at reducing arterial stiffness.
  • To evaluate the efficacy of various drug classes in mitigating age-related arterial stiffening.

Main Methods:

  • Literature review of pharmacological interventions.
  • Analysis of drug classes including antihypertensives, statins, antidiabetics, and others targeting arterial stiffness pathways.
  • Focus on drugs affecting blood pressure, inflammation, and vascular function.

Main Results:

  • Multiple drug classes, including ACE inhibitors, ARBs, calcium channel blockers, beta-blockers, diuretics, nitrates, statins, and others, demonstrated efficacy in reducing arterial stiffness.
  • Various pharmacological agents show potential in improving arterial health.
  • The reviewed drugs offer therapeutic options for managing arterial stiffness.

Conclusions:

  • Pharmacological interventions show promise in decreasing arterial stiffness.
  • Further clinical studies are required to confirm the impact of reducing arterial stiffness on major adverse cardiovascular and cerebrovascular events (MACCE).
  • Targeting arterial stiffness may represent a novel strategy for cardiovascular risk reduction.