Critical role of the GM-CSF signaling pathway in macrophage pro-repair activities

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Updated: Apr 25, 2026

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Eric Bernasconi1, Fabrizia D'Angelo, Pierre Michetti

  • 1Service of Gastroenterology and Hepatology, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
|August 30, 2014
PubMed
Abstract

Insights

Granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor signaling is essential for macrophage-driven intestinal wound repair. GM-CSF therapy can restore repair functions in macrophages from Crohn

Area of Science:

  • Immunology
  • Gastroenterology
  • Cell Biology

Background:

  • Macrophages are crucial for intestinal wound healing.
  • Molecular mechanisms regulating macrophage pro-repair functions are not fully understood.

Purpose of the Study:

  • To investigate the role of Granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor signaling in macrophage-mediated intestinal wound repair.
  • To evaluate GM-CSF therapy for restoring repair functions in macrophages from Crohn's disease patients.

Main Methods:

  • Differentiated murine bone marrow cells into macrophages.
  • Isolated human monocytes from Crohn's disease patients for macrophage differentiation.
  • Utilized in vitro models to assess macrophage repair activities.

Main Results:

  • GM-CSF receptor signaling is necessary for murine macrophages to promote epithelial repair.
  • Macrophages from Crohn's disease patients with active disease exhibited deficient repair properties.
  • GM-CSF therapy successfully restored the repair capabilities of these macrophages.

Conclusions:

  • The GM-CSF signaling pathway plays a vital role in the pro-repair functions of both mouse and human macrophages.
  • GM-CSF represents a potential therapeutic target for enhancing intestinal wound repair in conditions like Crohn's disease.

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