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Updated: Apr 25, 2026

Author Spotlight: Non-Contact Measurement of Tissue Mechanics in Live Chick Embryos Using Brillouin Microscopy
Published on: November 10, 2023
Comprehensive developmental mechanisms in gastroschisis
Frédéric Bargy1, Sylvie Beaudoin
1Department of Anatomy and Morphogenesis, Institut d'Anatomie des Saints Pères, Université Paris Descartes, Paris, France.
Introduction:
The development of gastroschisis remains an area of controversy. Various theories have been proposed, but none has ever been supported by a thorough embryological study.
Material And Methods:
We herein report anatomical and microscopic observations of the developing abdominal wall and cord of embryos and fetuses, along with clinical features of gastroschisis.
Results:
It appears that the developing cord normally has two parts, a firm left-sided part formed by the vessels and urachus, and a thin right-sided pouch covering the intestinal loops (the 'physiological umbilical hernia'), which could rupture, giving the basis of gastroschisis.
Discussion:
Gastroschisis could be the result of amniotic damage, possibly from some as yet unidentified toxin. Further bowel damage can be explained by the subsequent mesenteric injury.
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