Circulating progenitor cells and vascular dysfunction in chronic obstructive pulmonary disease.
Sandra Pizarro1, Jéssica García-Lucio1, Víctor I Peinado2
1Department of Pulmonary Medicine, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
Plos One
|August 30, 2014
Summary
In chronic obstructive pulmonary disease (COPD), circulating progenitor cells are reduced and linked to vascular issues, but not directly to smoking. This reduction appears to be a disease consequence, not a smoking-related factor.
Area of Science:
- Cardiovascular Research
- Pulmonary Medicine
- Hematology
Background:
- Chronic obstructive pulmonary disease (COPD) is linked to increased cardiovascular risk due to decreased progenitor cells and impaired vascular function.
- The origins of these vascular changes and their connection to pulmonary circulation alterations in COPD remain unclear.
Purpose of the Study:
- To determine if reduced circulating hematopoietic progenitor cells in COPD patients correlate with pulmonary hypertension or endothelial dysfunction.
- To investigate the relationship between progenitor cell counts, vascular function, and smoking status in COPD.
Main Methods:
- Studied 62 COPD patients and 35 controls (non-smokers and smokers).
- Quantified circulating CD45(+)CD34(+)CD133(+) progenitor cells using flow cytometry.
- Assessed systemic endothelial function via flow-mediated dilation and measured inflammatory/angiogenic markers.
Main Results:
- COPD patients had fewer circulating progenitor cells than controls; numbers did not differ between control smokers and non-smokers.
- COPD patients with pulmonary hypertension had higher progenitor cell counts.
- Systemic endothelial function was impaired in both control smokers and COPD patients. Progenitor cell count inversely correlated with systemic artery dilation in COPD patients.
- Elevated levels of IL-6, fibrinogen, hs-CRP, VEGF, and TNF were observed in COPD patients.
Conclusions:
- Pulmonary and systemic vascular impairment in COPD is associated with smoking.
- Reduced circulating hematopoietic progenitor cells in COPD are a consequence of the disease itself, not smoking.
- Progenitor cell reduction is not directly linked to pulmonary hypertension or endothelial dysfunction in COPD.
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