The frozen-thawed embryo transfer timing determined by serum progesterone level: a retrospective follow-up study
Zhe Dong1, Ling Sun1, Hanwang Zhang2
1Reproductive Medicine Center, Guangzhou Women and Children's Medical Center, No. 9, Jinsui Road, Guangzhou 510623, Guangdong, People's Republic of China.
Objective:
To compare the reproductive outcomes of frozen-thawed embryo transfer (FET) in nature cycle utilizing monitoring ovulation regimen (MOR) and monitoring progesterone (P) level regimen (MPR).
Study Design:
A retrospective analysis of records of 224 women who received FET procedures.
Result(S):
MPR was used in 60.3% (135/224) of cycles and MOR in 39.7% (89/224) of cycles. The clinical pregnancy rate per transfer was 63.0% in the MPR group and 48.3% in the MOR group (p=0.030). The implantation rates were 42.6% and 35.1%, respectively (p=0.001). The ongoing pregnancy rates per transfer (at 12 weeks' gestation) were 54.1% and 41.6%, respectively (p>0.05). A logistic regression analysis showed that the type of natural cycle regimen was a predictor of clinical pregnancy rate (odds ratio, 1.996; 95% confidence interval, 1.123-3.549; p=0.019). Other significant variables affecting clinical pregnancy rate was number of top-quality embryos transferred.
Conclusion(S):
Performing FET using MPR could achieve higher clinical pregnancy rate compared with MOR in a group of patients with the comparable demographic and cycle characteristics profile.
