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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

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Published on: June 3, 2020

Imaging frontotemporal lobar degeneration.

Janine Diehl-Schmid¹, Oezguer A Onur, Jens Kuhn

¹Department of Psychiatry and Psychotherapy, Technische Universität München, München, Germany.

Current Neurology and Neuroscience Reports

|August 31, 2014

Summary

This summary is machine-generated.

Frontotemporal lobar degeneration (FTLD) is a group of brain disorders affecting frontal and temporal lobes. Advanced imaging techniques like MRI and PET show promise for diagnosing FTLD, aiding early detection and treatment.

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Area of Science:

Neuroscience
Neurology

Background:

Frontotemporal lobar degeneration (FTLD) encompasses neurodegenerative disorders affecting the frontal and temporal lobes.
FTLD is a significant cause of dementia, particularly in individuals under 65, with prevalence comparable to Alzheimer's disease.
Key clinical syndromes include behavioral variant frontotemporal dementia and primary progressive aphasia variants.

Purpose of the Study:

To review the diagnostic utility of magnetic resonance imaging (MRI) and positron emission tomography (PET) in FTLD.
To provide a synopsis of current imaging biomarkers for FTLD.
To highlight advances in neuroimaging for FTLD diagnosis and treatment.

Main Methods:

Review of current literature on neuroimaging in FTLD.
Analysis of MRI-based biomarkers.
Evaluation of molecular imaging procedures (e.g., PET) in FTLD.

Main Results:

Neuropathological heterogeneity in FTLD complicates clinical diagnosis and treatment.
MRI and PET imaging methods have emerged as valuable biomarkers for FTLD.
These imaging techniques offer significant advances in early and reliable FTLD diagnosis.

Conclusions:

Neuroimaging plays a crucial role in overcoming diagnostic challenges in FTLD.
Continued research in MRI and PET applications is vital for improving FTLD patient outcomes.
The review underscores the importance of advanced imaging in understanding and managing FTLD.