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Updated: Apr 25, 2026

Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry
Published on: October 24, 2018
Recent advances in chiral separation of amino acids using capillary electromigration techniques
Alessandro Giuffrida1, Giuseppe Maccarrone2, Vincenzo Cucinotta2
1Institute of Biostructure and Bioimaging, National Research Council (CNR), via P. Gaifami 18, 95126 Catania, Italy.
Abstract:
This review highlights recent progresses in the chiral recognition and separation of amino acid enantiomers obtained by capillary electromigration techniques, using different chiral selectors and especially cyclodextrins, covering the literature published from January 2010 to March 2014. Sections are dedicated to the use of derivatization reagents and to the possibility to enantioseparate underivatized amino acids by using either ligand exchange capillary electrophoresis (LECE) and capillary electrophoresis (CE) coupled on line with mass spectrometry. A short insight on frontier nanomaterials is also given.
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