Related Experiment Videos
Does HIV cause salivary gland disease?
M Schiødt1, D Greenspan, J A Levy
1Oral AIDS Center, University of California, San Francisco.
AIDS (London, England)
|December 1, 1989
Summary
HIV-associated salivary gland disease (HIV-SGD) is not directly caused by HIV infection. Studies found no evidence of HIV in salivary gland tissues or saliva samples from affected patients.
Area of Science:
- Oral medicine
- Virology
- Pathology
Background:
- HIV-associated salivary gland disease (HIV-SGD) presents as major salivary gland enlargement and/or xerostomia.
- The direct role of human immunodeficiency virus (HIV) in HIV-SGD pathogenesis is unclear.
Purpose of the Study:
- To investigate the presence and role of HIV in salivary gland tissues and saliva of patients with HIV-SGD.
Main Methods:
- Immunohistochemistry was used to detect HIV in labial salivary gland biopsies from six patients.
- Saliva samples from seven patients were analyzed for HIV presence.
Main Results:
- HIV was detected in lymphocytes in only two of six salivary gland biopsies.
- HIV was not found in salivary gland epithelial cells.
- HIV was not detected in any of the 21 saliva samples analyzed.
Conclusions:
- The findings suggest that HIV-SGD is not caused by direct infection of salivary glands with HIV.
- The pathogenesis of HIV-SGD likely involves indirect mechanisms rather than direct viral invasion.