Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Haplotype-resolved DNA methylation at the <i>APOE</i> locus identifies allele-specific epigenetic signatures relevant to Alzheimer's disease risk.

NPJ dementia·2026

Same author

Is SORL1 a common genetic target across neurodegenerative diseases? A multi-ancestry biobank study.

Brain : a journal of neurology·2026

Same author

Region-specific transcriptional signatures of brain aging in the absence of neuropathology at the single-cell level.

npj aging·2026

Same author

The complete genome of the KOLF2.1J reference iPSC line.

bioRxiv : the preprint server for biology·2026

Same author

Sex effects on gene expression across the human cerebral cortex at cell type resolution.

Science (New York, N.Y.)·2026

Same author

Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice.

Molecular neurodegeneration·2026

Same journal

Glutamate-Glutamine metabolism and transport, implications in Parkinson's disease.

International review of neurobiology·2026

Same journal

Redox bioenergetics of neuronal senescence in Alzheimer's disease.

International review of neurobiology·2026

Same journal

Neurovascular coupling and energy substrate delivery in Alzheimer's disease.

International review of neurobiology·2026

Same journal

From metals to mitochondria: Linking trace elements to energy crisis in Alzheimer's disease.

International review of neurobiology·2026

Same journal

Invisible threats of microplastics induced toxicity: Oxidative and inflammatory pathways in the CNS and retina.

International review of neurobiology·2026

Same journal

Starved synapses: Gut microbiome dysbiosis and its role in Alzheimer's glucose impairment.

International review of neurobiology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 25, 2026

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

Transcriptomic changes in brain development.

Allissa A Dillman¹, Mark R Cookson¹

¹Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA.

International Review of Neurobiology

|August 31, 2014

Summary

This summary is machine-generated.

Brain development involves significant transcriptome changes, including gene expression and RNA editing, which shape proteomic diversity. High-throughput methods help understand gene regulation during this crucial maturation process.

Keywords:

Adult Development Editing Embryo Gene expression RNA-Seq Splicing

More Related Videos

Analysis of Translation in the Developing Mouse Brain using Polysome Profiling

Analysis of Translation in the Developing Mouse Brain using Polysome Profiling

Published on: May 22, 2021

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury

Published on: September 11, 2017

Related Experiment Videos

Last Updated: Apr 25, 2026

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

Analysis of Translation in the Developing Mouse Brain using Polysome Profiling

Analysis of Translation in the Developing Mouse Brain using Polysome Profiling

Published on: May 22, 2021

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury

Published on: September 11, 2017

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

The developing brain undergoes extensive transcriptome alterations.
Changes in gene expression, RNA splicing, and RNA editing contribute to proteomic diversity.
Noncoding RNAs (miRNAs, lncRNAs) play a role in regulating the transcriptional landscape during brain maturation.

Purpose of the Study:

To review known changes in the transcriptome during brain development.
To highlight the application of high-throughput approaches in studying these changes.
To infer mechanisms of gene expression control in the maturing brain.

Main Methods:

Analysis of whole gene expression.
Examination of alternative exon usage.
Assessment of RNA editing at the single base pair level.
Investigation of noncoding RNA (miRNA, lncRNA) interactions with mRNA.
Focus on high-throughput sequencing and analysis techniques.

Main Results:

Significant differences observed in gene expression, alternative splicing, and RNA editing between embryonic and mature brains.
Noncoding RNAs demonstrate dynamic changes and interactions with mRNAs, influencing the transcriptome.
High-throughput methods provide comprehensive insights into the complexity of transcriptional regulation during brain development.

Conclusions:

Transcriptome changes are fundamental to brain development and proteomic diversification.
RNA editing and noncoding RNA regulation are key mechanisms in brain maturation.
High-throughput technologies are essential for deciphering the intricate control of gene expression in the developing brain.