Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia l: Introduction01:22

Dementia l: Introduction

29
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
29
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

16
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
16
Neural Regulation01:37

Neural Regulation

34.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
34.6K
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K
Long-term Depression01:05

Long-term Depression

27.2K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
27.2K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of an <i>in vivo</i>, screenable, split-luciferase based model of huntingtin multimerization.

iScience·2026
Same author

Elevation of the mechanically-sensitive e protein emerin links nuclear mechanotransduction to tau-induced cytoskeletal remodeling in neurons.

Nucleus (Austin, Tex.)·2026
Same author

Multidimensional Safety Assessment of a Low-Intensity Scanning Ultrasound (SUS) Protocol in Sheep.

Ultrasound in medicine & biology·2026
Same author

Emerging directions in tauopathy research.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Single-cell eQTL mapping reveals convergent glial-neuronal risk architecture in Parkinson's disease.

bioRxiv : the preprint server for biology·2026
Same author

Case Study 11: A 67-Year-Old Man With Behavioral Disturbances and Frequent Falls.

The Journal of neuropsychiatry and clinical neurosciences·2026

Related Experiment Video

Updated: Apr 25, 2026

Mass Histology to Quantify Neurodegeneration in Drosophila
06:34

Mass Histology to Quantify Neurodegeneration in Drosophila

Published on: December 15, 2016

9.9K

Connecting the dots between tau dysfunction and neurodegeneration.

Bess Frost1, Jürgen Götz2, Mel B Feany1

  • 1Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Trends in Cell Biology
|August 31, 2014
PubMed
Summary

This review explores the molecular mechanisms driving tauopathies, such as Alzheimer's disease (AD). It highlights how abnormal tau protein phosphorylation leads to neurodegeneration and discusses therapeutic strategies targeting this pathway.

Keywords:
Alzheimeractincell cyclechromatintauopathytherapeutics

More Related Videos

Visualizing Synaptic Degeneration in Adult Drosophila in Association with Neurodegeneration
06:10

Visualizing Synaptic Degeneration in Adult Drosophila in Association with Neurodegeneration

Published on: May 13, 2020

6.8K
Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy
07:02

Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy

Published on: January 19, 2019

6.1K

Related Experiment Videos

Last Updated: Apr 25, 2026

Mass Histology to Quantify Neurodegeneration in Drosophila
06:34

Mass Histology to Quantify Neurodegeneration in Drosophila

Published on: December 15, 2016

9.9K
Visualizing Synaptic Degeneration in Adult Drosophila in Association with Neurodegeneration
06:10

Visualizing Synaptic Degeneration in Adult Drosophila in Association with Neurodegeneration

Published on: May 13, 2020

6.8K
Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy
07:02

Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy

Published on: January 19, 2019

6.1K

Area of Science:

  • Neuroscience
  • Pathology
  • Pharmacology

Background:

  • Tauopathies are fatal neurodegenerative diseases characterized by abnormal tau protein aggregation.
  • Alzheimer's disease (AD) is a prominent tauopathy, necessitating research into its underlying mechanisms.
  • Understanding tau pathology is crucial for developing effective treatments.

Purpose of the Study:

  • To review the cascade of events initiated by pathological tau.
  • To highlight current and potential therapeutic strategies targeting tauopathy pathways.
  • To elucidate the sequence from tau dysfunction to neuronal death.

Main Methods:

  • Literature review of recent findings on tau phosphorylation and aggregation.
  • Analysis of the molecular events leading to neurodegeneration in tauopathies.
  • Synthesis of information on therapeutic interventions for tauopathies.

Main Results:

  • Pathological tau triggers a cascade leading to neuronal death.
  • Abnormal tau phosphorylation and aggregation are key drivers of disease progression.
  • Recent advancements have shed light on the sequence of events in tau dysfunction.

Conclusions:

  • Targeting the pathological tau cascade offers promising therapeutic avenues.
  • Further research into the causes of abnormal tau phosphorylation is essential.
  • Developing interventions for tauopathies, including AD, remains a critical goal.