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Updated: Apr 25, 2026

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Pressurized liquid extraction and liquid chromatography-tandem mass spectrometry applied to determine iodinated X-ray
S Echeverría1, F Borrull1, E Pocurull1
1Department of Analytical Chemistry and Organic Chemistry, Univesitat Rovira i Virgili, Sescelades Campus, Marcel·lí Domingo s/n, Tarragona 43007, Spain.
Abstract:
Pressurized liquid extraction (PLE) has been successfully applied for the first time to the extraction of five iodinated X-ray contrast media from sludge. Once optimized all PLE parameters, the extract has been analyzed by liquid chromatography-tandem mass spectrometry, being the method developed sensible enough to reach limit of quantifications (LOQs) of 25 μg kg(-1) (d.w.). The developed method has been applied to the analysis of sludge from urban sewage treatment plants and although some compounds such as iopromide, diatrizoic acid and iopamidol have been identified, their concentrations have been lower than their LOQs.
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