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Cardiac amyloidosis: a report of two cases

Chandrashekhar Munjewar1, Rahul Agrawal1, Satyavan Sharma2

  • 1Registrar, Department of Cardiology, Bombay Hospital Institute of Medical Sciences, New Marine Lines, Mumbai 400020, Maharashtra, India.

Indian Heart Journal
|September 1, 2014
PubMed

Insights

Cardiac amyloidosis, a rare fatal condition, is linked to plasma cell dyscrasias. Early diagnosis via clinical suspicion and echocardiography is crucial for initiating specific treatments, though cardiac support offers limited success.

Area of Science:

  • Cardiology
  • Hematology
  • Oncology

Background:

  • Cardiac amyloidosis is a rare, often fatal, multisystem disorder.
  • It is frequently associated with plasma cell dyscrasias.
  • Diagnosis can be challenging due to its rarity and complex presentation.

Observation:

  • Two cases of cardiac amyloidosis associated with plasma cell dyscrasia are presented.
  • Key diagnostic indicators included high clinical suspicion, specific echocardiographic findings (ventricular thickening, diastolic dysfunction, biatrial enlargement), and elevated cardiac biomarkers.
  • These findings highlight the importance of a comprehensive diagnostic approach.

Findings:

  • The study underscores the diagnostic utility of combining clinical acumen, advanced imaging, and biomarker analysis in identifying cardiac amyloidosis.
  • Early detection is emphasized as critical for timely intervention.

Implications:

  • Prompt initiation of amyloid-specific therapies, alongside supportive cardiac care, is recommended.
  • While cardiac treatment is primarily supportive and often yields disappointing results, early intervention may improve outcomes.
  • Further research into effective therapeutic strategies for cardiac amyloidosis is warranted.

Keywords:
Cardiac amyloidosisPlasma cell dyscrasiaWaldenstrom's macroglobulinemia

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