Related Experiment Video
Updated: Apr 25, 2026
In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
Published on: February 16, 2024
Generation of osteoporosis in immune-compromised mice for stem cell therapy
Reeva Aggarwal1, Vincent J Pompili, Hiranmoy Das
1Cardiovascular Stem Cell Laboratories, The Dorothy M. Davis Heart and Lung Research Institute, Wexner Medical Center at The Ohio State University, 460 W. 12th Avenue, BRT 394, Columbus, OH, 43210, USA.
Abstract:
To evaluate therapeutic efficacy and to investigate involved molecular mechanisms of cell-based therapy in osteoporosis, the generation of a clinically relevant model is critically important. Herein, we describe detailed methods in generation of an immune-deficient osteoporotic murine model, and application of human umbilical cord blood-derived stem cells to assess their therapeutic efficacy.
