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Updated: Apr 25, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
Modulation of autoimmune diseases by iPS cells
Fengyang Lei1, Rizwanul Haque, Xiaofang Xiong
1Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Regulatory T (Treg) cells can treat autoimmune diseases by suppressing self-reactive immune cells. Induced pluripotent stem (iPS) cells can generate large numbers of Treg cells for therapeutic use.
Area of Science:
- Immunology
- Stem Cell Biology
- Autoimmune Diseases
Background:
- Autoimmune diseases stem from self-reactive immune cells, with current treatments relying on immunosuppression.
- Regulatory T (Treg) cells are crucial for maintaining immune homeostasis by suppressing immune responses.
- Supplementing Treg cells offers a potential therapeutic strategy for autoimmune disorders.
Purpose of the Study:
- To address the scarcity of Treg cells for therapeutic applications.
- To explore the potential of induced pluripotent stem (iPS) cells for Treg cell generation.
Main Methods:
- Utilizing induced pluripotent stem (iPS) cells as a source for Treg cell generation.
- Developing methods to produce a significant quantity of Treg cells.
Main Results:
- Successfully generated a substantial number of Treg cells from iPS cells.
- Demonstrated the feasibility of producing therapeutically relevant quantities of Treg cells.
Conclusions:
- iPS cell-derived Treg cells offer a promising solution for Treg cell scarcity in autoimmune disease treatment.
- This approach holds potential for developing novel preventative and therapeutic strategies for autoimmune conditions.
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