QTc changes after meal intake: sex differences and correlates.
Katerina Hnatkova1, Donna Kowalski2, James J Keirns2
1Imperial College, London, UK.
Journal of Electrocardiology
|September 1, 2014
Summary
Food intake causes significant heart rate changes and divergent effects on QTc intervals. Lunch shortens QTc, while dinner prolongs it, suggesting meal-induced QTc changes need further evaluation for assay sensitivity in thorough QT/QTc (TQT) studies.
Area of Science:
- Cardiology
- Clinical Pharmacology
Background:
- Food-induced QTc shortening is a proposed measure for assay sensitivity in thorough QT/QTc (TQT) studies.
- This study investigated food effects on QTc intervals using data from a large clinical trial.
Purpose of the Study:
- To evaluate the impact of meals on QTc intervals in healthy subjects.
- To determine if meal-induced QTc changes are reliable for assessing assay sensitivity in TQT studies.
Main Methods:
- 12-lead Holter recordings were obtained from 352 healthy subjects (176 female, 176 male) over four sessions.
- Heart rate and QTc intervals were measured during fasting and post-meal periods (lunch and dinner).
- QTc intervals were individually corrected for heart rate and QT/RR hysteresis.
Main Results:
- Both lunch and dinner induced statistically significant heart rate accelerations in both men and women.
- Lunch resulted in a significant QTc interval shortening in women and men.
- Dinner led to a significant QTc interval prolongation in both women and men.
Conclusions:
- Systematic, divergent diurnal changes in QTc intervals were observed: shortening after lunch and lengthening after dinner.
- The utility of meal-induced QTc changes for assay sensitivity in TQT studies requires further investigation due to these opposing effects.
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