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Updated: Apr 25, 2026

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
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Pharmacokinetics in IBD: ready for prime time?

Xavier Roblin, Melanie Rinaudo, Miles Peter Sparrow

  • 1Department of Gastroenterology, CHU de Saint-Etienne, 42023 Saint-Etienne, France. xavier.roblin@chu-st-etienne.fr.

Current Drug Targets
|September 1, 2014
PubMed

This review discusses the rationale behind recommending immunopharmacological guidance of long-term therapies with anti-TNF-α specific biotherapies. "Arguments why therapeutic decision-making should not rely on clinical outcomes alone are presented. Central to this is that the use of theranostics (i.e., monitoring circulating levels of functional anti-TNF-α drugs and antidrug antibodies) would markedly improve treatment because therapies can be tailored to individual patients and provide more effective and economical long-term clinical benefits while minimising risk of side effects. Large-scale immunopharmacological knowledge of the pharmacokinetics of TNF-α biopharmaceuticals in individual patients would also help industry to develop more effective and safer TNF-α inhibitors" [1].

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